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Augmentation of Chemotherapeutically Induced Remission of a Murine Leukemia by a Chemical Immunoadjuvant

Viral Biology Branch, National Cancer Institute, Bethesda, Maryland 20014

The effect of combining chemotherapy and immunostimulation, induced by a chemical, against a murine lymphoid leukemia was investigated. When tetramisole or levamisole were used following one administration of 1,3-bis(2-chloroethyl)-1-nitrosourea, a significantly higher percentage of long-term surviviors occurred in contrast to the groups of animals treated with drug or immunostimulant alone. The administration of chemical immunostimulator was effective at any time during 1,3-bis(2-chloroethyl)-l-nitrosourea-induced remission. Low doses of the chemicals were as effective as higher doses in evoking this synergistic response. The role of chemical immunostimulators in combination with antitumor drugs is discussed.

Received 4/30/73. Accepted 7/13/73.