| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Memorial Sloan-Kettering Cancer Center, New York, New York 10021
Continuous cell lines, SK-N-SH and SK-N-MC, were established in cell culture from human metastatic neuroblastoma tissue and maintained in vitro for 1 to 2 years. SK-N-SH comprises two morphologically distinctive cell types, a small spiny cell and a large epithelioid cell. SK-N-MC is composed of small fibroblast-like cells with scant cytoplasm. In monolayer culture both cell lines form disoriented growth patterns and reach high saturation densities. Population-doubling times were 44 and 32 hr for SK-N-SH and SK-N-MC, respectively. Inoculum levels of 107 cells of both lines produced tumors confirmed by histopathological examination, at frequencies of 30 to 40% in cheek pouches of conditioned Syrian hamsters. SK-N-SH cells are characterized by high dopamine-ß-hydroxylase activity while SK-N-MC cells have no detectable activity. However, for SK-N-MC but not SK-N-SH, the presence of intracellular catecholamine was indicated by formaldehyde-induced fluorescence. The lines are near-diploid with several chromosomal markers; SK-N-MC cells contain double-minute chromosomes. Growth, biochemical, and cytogenetic properties confirmed that the lines comprise malignant cells of neurogenic origin.
1 This investigation was supported in part by National Cancer Institute Grant CA 08748 and by the Ann Marie O'Brien Neuroblastoma Fund.
Received 4/23/73. Accepted 7/17/73.
This article has been cited by other articles:
|
|
 |
|
  R. Werdehausen, S. Fazeli, S. Braun, H. Hermanns, F. Essmann, M. W. Hollmann, I. Bauer, and M. F. Stevens Apoptosis induction by different local anaesthetics in a neuroblastoma cell line Br. J. Anaesth., November 1, 2009; 103(5): 711 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. S. Zagon, R. N. Donahue, and P. J. McLaughlin Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2009; 297(4): R1154 - R1161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Marimpietri, C. Brignole, B. Nico, F. Pastorino, A. Pezzolo, F. Piccardi, M. Cilli, D. Di Paolo, G. Pagnan, L. Longo, et al. Combined Therapeutic Effects of Vinblastine and Rapamycin on Human Neuroblastoma Growth, Apoptosis, and Angiogenesis Clin. Cancer Res., July 1, 2007; 13(13): 3977 - 3988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Oppenheimer, N.-K. Cheung, and W. L. Gerald The RET oncogene is a critical component of transcriptional programs associated with retinoic acid-induced differentiation in neuroblastoma Mol. Cancer Ther., April 1, 2007; 6(4): 1300 - 1309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Cui, B. Hu, T. Li, J. Ma, G. Alam, W. T. Gunning, and H.-F. Ding Bmi-1 Is Essential for the Tumorigenicity of Neuroblastoma Cells Am. J. Pathol., April 1, 2007; 170(4): 1370 - 1378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Frgala, O. Kalous, R. T. Proffitt, and C. P. Reynolds A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations Mol. Cancer Ther., March 1, 2007; 6(3): 886 - 897. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. C. Unsworth, T. Aasen, S. McElwaine, and D. P. Kelsell Tissue-specific effects of wild-type and mutant connexin 31: a role in neurite outgrowth Hum. Mol. Genet., January 15, 2007; 16(2): 165 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Cui, J. Ma, J. Ding, T. Li, G. Alam, and H.-F. Ding Bmi-1 Regulates the Differentiation and Clonogenic Self-renewal of I-type Neuroblastoma Cells in a Concentration-dependent Manner J. Biol. Chem., November 10, 2006; 281(45): 34696 - 34704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yogev-Falach, O. Bar-Am, T. Amit, O. Weinreb, and M. B. H. Youdim A multifunctional, neuroprotective drug, ladostigil (TV3326), regulates holo-APP translation and processing FASEB J, October 1, 2006; 20(12): 2177 - 2179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Moreau, P. McGrady, W. B. London, H. Shimada, S. L. Cohn, J. M. Maris, L. Diller, A. T. Look, and R. E. George Does MYCN Amplification Manifested as Homogeneously Staining Regions at Diagnosis Predict a Worse Outcome in Children with Neuroblastoma? A Children's Oncology Group Study. Clin. Cancer Res., October 1, 2006; 12(19): 5693 - 5697. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Brignole, D. Marimpietri, F. Pastorino, B. Nico, D. Di Paolo, M. Cioni, F. Piccardi, M. Cilli, A. Pezzolo, M. V. Corrias, et al. Effect of bortezomib on human neuroblastoma cell growth, apoptosis, and angiogenesis. J Natl Cancer Inst, August 16, 2006; 98(16): 1142 - 1157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Frassetto, C. R. Schlieve, C. J. Lieven, A. A. Utter, M. V. Jones, N. Agarwal, and L. A. Levin Kinase-Dependent Differentiation of a Retinal Ganglion Cell Precursor Invest. Ophthalmol. Vis. Sci., January 1, 2006; 47(1): 427 - 438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hecht, J. H. Schulte, A. Eggert, J. Wilting, and L. Schweigerer The neurotrophin receptor TrkB cooperates with c-Met in enhancing neuroblastoma invasiveness Carcinogenesis, December 1, 2005; 26(12): 2105 - 2115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. DeJesus, D. Franco, A. Paul, E. Wimmer, and J. Cello Mutation of a Single Conserved Nucleotide between the Cloverleaf and Internal Ribosome Entry Site Attenuates Poliovirus Neurovirulence J. Virol., November 15, 2005; 79(22): 14235 - 14243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Peng, J. D. Fryer, R. S. Hurst, K. M. Schroeder, A. A. George, S. Morrissy, V. E. Groppi, S. S. Leonard, and R. J. Lukas High-Affinity Epibatidine Binding of Functional, Human {alpha}7-Nicotinic Acetylcholine Receptors Stably and Heterologously Expressed de Novo in Human SH-EP1 Cells J. Pharmacol. Exp. Ther., April 1, 2005; 313(1): 24 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Cui, T. Li, and H.-F. Ding Linking of N-Myc to Death Receptor Machinery in Neuroblastoma Cells J. Biol. Chem., March 11, 2005; 280(10): 9474 - 9481. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Sitek, O. Apostolov, K. Stuhler, K. Pfeiffer, H. E. Meyer, A. Eggert, and A. Schramm Identification of Dynamic Proteome Changes Upon Ligand Activation of Trk-Receptors Using Two-dimensional Fluorescence Difference Gel Electrophoresis and Mass Spectrometry Mol. Cell. Proteomics, March 1, 2005; 4(3): 291 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Yang, P. Zage, D. Kagan, Y. Tian, R. Seshadri, H. R. Salwen, S. Liu, A. Chlenski, and S. L. Cohn Association of Epigenetic Inactivation of RASSF1A with Poor Outcome in Human Neuroblastoma Clin. Cancer Res., December 15, 2004; 10(24): 8493 - 8500. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Staege, C. Hutter, I. Neumann, S. Foja, U. E. Hattenhorst, G. Hansen, D. Afar, and S. E. G. Burdach DNA Microarrays Reveal Relationship of Ewing Family Tumors to Both Endothelial and Fetal Neural Crest-Derived Cells and Define Novel Targets Cancer Res., November 15, 2004; 64(22): 8213 - 8221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-i. Nagai, T. Yazawa, K. Okudela, H. Kigasawa, H. Kitamura, and H. Osaka Retinoic Acid Induces Neuroblastoma Cell Death by Inhibiting Proteasomal Degradation of Retinoic Acid Receptor {alpha} Cancer Res., November 1, 2004; 64(21): 7910 - 7917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lindskog, C. Spenger, J. Jarvet, A. Graslund, and P. Kogner Predicting Resistance or Response to Chemotherapy by Proton Magnetic Resonance Spectroscopy in Neuroblastoma J Natl Cancer Inst, October 6, 2004; 96(19): 1457 - 1466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Lovat, F. Di Sano, M. Corazzari, B. Fazi, R. P. Donnorso, A. D. J. Pearson, A. G. Hall, C. P. F. Redfern, and M. Piacentini Gangliosides Link the Acidic Sphingomyelinase-Mediated Induction of Ceramide to 12-Lipoxygenase-Dependent Apoptosis of Neuroblastoma in Response to Fenretinide J Natl Cancer Inst, September 1, 2004; 96(17): 1288 - 1299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Karlsson, I. Ora, I. Porn-Ares, and S. Pahlman Arsenic Trioxide-Induced Death of Neuroblastoma Cells Involves Activation of Bax and Does Not Require p53 Clin. Cancer Res., May 1, 2004; 10(9): 3179 - 3188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Woodworth, P. Pesheva, D. Fiete, and J. U. Baenziger Neuronal-specific Synthesis and Glycosylation of Tenascin-R J. Biol. Chem., March 12, 2004; 279(11): 10413 - 10421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Rorie, V. D. Thomas, P. Chen, H. H. Pierce, J. P. O'Bryan, and B. E. Weissman The Ews/Fli-1 Fusion Gene Switches the Differentiation Program of Neuroblastomas to Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumors Cancer Res., February 15, 2004; 64(4): 1266 - 1277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Bian, T. D. Giordano, H.-J. Lin, G. Solomon, V. P. Castle, and A. W. Opipari Jr. Chemotherapy-induced Apoptosis of S-type Neuroblastoma Cells Requires Caspase-9 and Is Augmented by CD95/Fas Stimulation J. Biol. Chem., February 6, 2004; 279(6): 4663 - 4669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Corazzari, P. E. Lovat, S. Oliverio, A. D. J. Pearson, M. Piacentini, and C. P. F. Redfern Growth and DNA Damage-Inducible Transcription Factor 153 Mediates Apoptosis in Response to Fenretinide but Not Synergy between Fenretinide and Chemotherapeutic Drugs in Neuroblastoma Mol. Pharmacol., December 1, 2003; 64(6): 1370 - 1378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Lovat, S. Oliverio, M. Corazzari, C. Rodolfo, M. Ranalli, B. Goranov, G. Melino, C. P. F. Redfern, and M. Piacentini Bak: A Downstream Mediator of Fenretinide-Induced Apoptosis of SH-SY5Y Neuroblastoma Cells Cancer Res., November 1, 2003; 63(21): 7310 - 7313. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Chen, J. Vaughan, and W. W. Vale Glucocorticoids Regulate the Expression of the Mouse Urocortin II Gene: A Putative Connection between the Corticotropin-Releasing Factor Receptor Pathways Mol. Endocrinol., August 1, 2003; 17(8): 1622 - 1639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Carlin, R. J. Mairs, A. G. McCluskey, D. A. Tweddle, A. Sprigg, C. Estlin, J. Board, R. E. George, C. Ellershaw, A. D. J. Pearson, et al. Development of a Real-Time Polymerase Chain Reaction Assay for Prediction of the Uptake of Meta-[131I]iodobenzylguanidine by Neuroblastoma Tumors Clin. Cancer Res., August 1, 2003; 9(9): 3338 - 3344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kametaka, M. Shibata, K. Moroe, S. Kanamori, Y. Ohsawa, S. Waguri, P. J. Sims, K. Emoto, M. Umeda, and Y. Uchiyama Identification of Phospholipid Scramblase 1 as a Novel Interacting Molecule with beta -Secretase (beta -Site Amyloid Precursor Protein (APP) Cleaving Enzyme (BACE)) J. Biol. Chem., April 18, 2003; 278(17): 15239 - 15245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Bian, A. W. Opipari Jr., A. B. Ratanaproeksa, A. E. Boitano, P. C. Lucas, and V. P. Castle Constitutively Active NFkappa B Is Required for the Survival of S-type Neuroblastoma J. Biol. Chem., October 25, 2002; 277(44): 42144 - 42150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Lovat, S. Oliverio, M. Ranalli, M. Corazzari, C. Rodolfo, F. Bernassola, K. Aughton, M. Maccarrone, Q. D. C. Hewson, A. D. J. Pearson, et al. GADD153 and 12-Lipoxygenase Mediate Fenretinide-induced Apoptosis of Neuroblastoma Cancer Res., September 15, 2002; 62(18): 5158 - 5167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ricordy, G. Gensabella, E. Cacci, and G. Augusti-Tocco Impairment of cell cycle progression by aflatoxin B1 in human cell lines Mutagenesis, May 1, 2002; 17(3): 241 - 249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Eggert, M. A. Grotzer, N. Ikegaki, X.-g. Liu, A. E. Evans, and G. M. Brodeur Expression of the Neurotrophin Receptor TrkA Down-Regulates Expression and Function of Angiogenic Stimulators in SH-SY5Y Neuroblastoma Cells Cancer Res., March 1, 2002; 62(6): 1802 - 1808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zander, J. Takahashi, K. H. El Hachimi, H. Fujigasaki, V. Albanese, A. S. Lebre, G. Stevanin, C. Duyckaerts, and A. Brice Similarities between spinocerebellar ataxia type 7 (SCA7) cell models and human brain: proteins recruited in inclusions and activation of caspase-3 Hum. Mol. Genet., October 1, 2001; 10(22): 2569 - 2579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Mora, N.-K. V. Cheung, G. Juan, P. Illei, I. Cheung, M. Akram, S. Chi, M. Ladanyi, C. Cordon-Cardo, and W. L. Gerald Neuroblastic and Schwannian Stromal Cells of Neuroblastoma Are Derived from a Tumoral Progenitor Cell Cancer Res., September 1, 2001; 61(18): 6892 - 6898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Poulaki, N. Mitsiades, M. E. Romero, and M. Tsokos Fas-mediated Apoptosis in Neuroblastoma Requires Mitochondrial Activation and Is Inhibited by FLICE Inhibitor Protein and bcl-2 Cancer Res., June 1, 2001; 61(12): 4864 - 4872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mardy, Y. Miura, F. Endo, I. Matsuda, and Y. Indo Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor Hum. Mol. Genet., February 1, 2001; 10(3): 179 - 188. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. V. Gaitonde, W. Qi, R. R. Falsey, N. Sidell, and J. D. Martinez Morphologic Conversion of a Neuroblastoma-derived Cell Line by E6-mediated p53 Degradation Cell Growth Differ., January 1, 2001; 12(1): 19 - 27. [Abstract] [Full Text]
|
|
|
|
|
|
A. Edsjö, B. Hallberg, S. Fagerström, C. Larsson, H. Axelson, and S. Påhlman Differences in Early and Late Responses between Neurotrophin-stimulated trkA- and trkC-transfected SH-SY5Y Neuroblastoma Cells Cell Growth Differ., January 1, 2001; 12(1): 39 - 50. [Abstract] [Full Text]
|
|
|
|
|
|
P. M. Thompson, J. M. Maris, M. D. Hogarty, R. C. Seeger, C. P. Reynolds, G. M. Brodeur, and P. S. White Homozygous Deletion of CDKN2A (p16INK4a/p14ARF) but not within 1p36 or at Other Tumor Suppressor Loci in Neuroblastoma Cancer Res., January 1, 2001; 61(2): 679 - 686. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. A. Shapiro, C. Xu, and D. M. Dorsa Differential Transcriptional Regulation of Rat Vasopressin Gene Expression by Estrogen Receptor {alpha} and {beta} Endocrinology, November 1, 2000; 141(11): 4056 - 4064. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Jannini, A. Crescenzi, N. Rucci, E. Screponi, E. Carosa, A. De Matteis, E. Macchia, G. d’Amati, and M. D’Armiento Ontogenetic Pattern of Thyroid Hormone Receptor Expression in the Human Testis J. Clin. Endocrinol. Metab., September 1, 2000; 85(9): 3453 - 3457. [Abstract] [Full Text]
|
|
|
|
|
|
R. Levi and N. C. E. Smith Histamine H3-Receptors: A New Frontier in Myocardial Ischemia J. Pharmacol. Exp. Ther., March 1, 2000; 292(3): 825 - 830. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Wang, P. Einhorn, T. J. Triche, R. C. Seeger, and C. P. Reynolds Expression of Protein Gene Product 9.5 and Tyrosine Hydroxylase in Childhood Small Round Cell Tumors Clin. Cancer Res., February 1, 2000; 6(2): 551 - 558. [Abstract] [Full Text]
|
|
|
|
|
|
G. S. Kelner, M. Lee, M. E. Clark, D. Maciejewski, D. McGrath, S. Rabizadeh, T. Lyons, D. Bredesen, P. Jenner, and R. A. Maki The Copper Transport Protein Atox1 Promotes Neuronal Survival J. Biol. Chem., January 7, 2000; 275(1): 580 - 584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Kim, T. Matsuo, K.-H. Lee, and C. J. Thiele Up-Regulation of Insulin-Like Growth Factor-II Expression Is a Feature of TrkA but Not TrkB Activation in SH-SY5Y Neuroblastoma Cells Am. J. Pathol., November 1, 1999; 155(5): 1661 - 1670. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Maris and K. K. Matthay Molecular Biology of Neuroblastoma J. Clin. Oncol., July 1, 1999; 17(7): 2264 - 2264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Chambery, S. Mohseni-Zadeh, B. d. Galle, and S. Babajko N-myc Regulation of Type I Insulin-like Growth Factor Receptor in a Human Neuroblastoma Cell Line Cancer Res., June 1, 1999; 59(12): 2898 - 2902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Farina, A. Tacconelli, A. Vacca, M. Maroder, A. Gulino, and A. R. Mackay Transcriptional Up-Regulation of Matrix Metalloproteinase-9 Expression during Spontaneous Epithelial to Neuroblast Phenotype Conversion by SK-N-SH Neuroblastoma Cells, Involved in Enhanced Invasivity, Depends upon GT-Box and Nuclear Factor {{kappa}}B Elements Cell Growth Differ., May 1, 1999; 10(5): 353 - 367. [Abstract] [Full Text]
|
|
|
|
 |
|
 F. Mannello, M. Malatesta, F. Luchetti, S. Papa, S. Battistelli, and G. Gazzanelli Immunoreactivity, Ultrastructural Localization, and Transcript Expression of Prostate-specific Antigen in Human Neuroblastoma Cell Lines Clin. Chem., January 1, 1999; 45(1): 78 - 84. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Villani, M. Greco, S. Papa, and G. Attardi Low Reserve of Cytochrome c Oxidase Capacity in Vivo in the Respiratory Chain of a Variety of Human Cell Types J. Biol. Chem., November 27, 1998; 273(48): 31829 - 31836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Li, X. Qu, and A. M. Schmidt Sp1-binding Elements in the Promoter of RAGE Are Essential for Amphoterin-mediated Gene Expression in Cultured Neuroblastoma Cells J. Biol. Chem., November 20, 1998; 273(47): 30870 - 30878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ferrari, M. Pfahl, and G. Levi Retinoic Acid Receptor gamma 1 (RARgamma 1) Levels Control RARbeta 2 Expression in SK-N-BE2(c) Neuroblastoma Cells and Regulate a Differentiation-Apoptosis Switch Mol. Cell. Biol., November 1, 1998; 18(11): 6482 - 6492. [Abstract] [Full Text]
|
|
|
|
 |
|
 X. Song and M. Ehrich MPTP-Induced Modulation of Neurotransmitters in SH-SY5Y Human Neuroblastoma Cells International Journal of Toxicology, October 1, 1998; 17(6): 677 - 701. [Abstract] [PDF]
|
|
|
|
|
|
J. M. Pyper, J. E. Clements, and M. C. Zink The Nucleolus Is the Site of Borna Disease Virus RNA Transcription and Replication J. Virol., September 1, 1998; 72(9): 7697 - 7702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. New, S. B. Maggirwar, L. G. Epstein, S. Dewhurst, and H. A. Gelbard HIV-1 Tat Induces Neuronal Death via Tumor Necrosis Factor-alpha and Activation of Non-N-methyl-D-aspartate Receptors by a NFkappa B-Independent Mechanism J. Biol. Chem., July 10, 1998; 273(28): 17852 - 17858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Mannello, F. Luchetti, E. Falcieri, S. Papa, and G. Gazzanelli Prostate-specific Antigen Expression in Neuroblastoma Cell Lines Clin. Chem., June 1, 1998; 44(6): 1362 - 1363. [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Francis, A. W. Sandrock, P. G. Bhide, J.-P. Vonsattel, and R. H. Brown Jr. Heterogeneity of subcellular localization and electrophoretic mobility of survival motor neuron (SMN) protein in mammalian neural cells and tissues PNAS, May 26, 1998; 95(11): 6492 - 6497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang, M. Lesort, R. P. Guttmann, and G. V. W. Johnson Modulation of the in Situ Activity of Tissue Transglutaminase by Calcium and GTP J. Biol. Chem., January 23, 1998; 273(4): 2288 - 2295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fagerstrom, S. Pahlman, and E. Nanberg Protein Kinase C-dependent Tyrosine Phosphorylation of p130cas in Differentiating Neuroblastoma Cells J. Biol. Chem., January 23, 1998; 273(4): 2336 - 2343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Charrasse, M Schroeder, C Gauthier-Rouviere, F Ango, L Cassimeris, D. Gard, and C Larroque The TOGp protein is a new human microtubule-associated protein homologous to the Xenopus XMAP215 J. Cell Sci., January 5, 1998; 111(10): 1371 - 1383. [Abstract] [PDF]
|
|
|
|
|
|
B. B. Chang, S. P. Persengiev, J. G. de Diego, M. P. Sacristan, D. M. Zanca, and D. L. Kilpatrick Proximal Promoter Sequences Mediate Cell-specific and Elevated Expression of the Favorable Prognosis Marker TrkA in Human Neuroblastoma Cells J. Biol. Chem., January 2, 1998; 273(1): 39 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Criado, E. Dominguez del Toro, C. Carrasco-Serrano, F. I. Smillie, J. M. Juiz, S. Viniegra, and J. J. Ballesta Differential Expression of alpha -Bungarotoxin-Sensitive Neuronal Nicotinic Receptors in Adrenergic Chromaffin Cells: A Role for Transcription Factor Egr-1 J. Neurosci., September 1, 1997; 17(17): 6554 - 6564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gaetano, T. Matsuo, and C. J. Thiele Identification and Characterization of a Retinoic Acid-regulated Human Homologue of the unc-33-like Phosphoprotein Gene (hUlip) from Neuroblastoma Cells J. Biol. Chem., May 2, 1997; 272(18): 12195 - 12201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Menouny, M. Binoux, and S. Babajko Role of Insulin-Like Growth Factor Binding Protein-2 and Its Limited Proteolysis in Neuroblastoma Cell Proliferation: Modulation by Transforming Growth Factor-{beta} and Retinoic Acid Endocrinology, February 1, 1997; 138(2): 683 - 690. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Chagnovich and S. L. Cohn Binding of a 40-kDa Protein to the N-myc 3'-Untranslated Region Correlates with Enhanced N-myc Expression in Human Neuroblastoma J. Biol. Chem., December 27, 1996; 271(52): 33580 - 33586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Chagnovich, B. E. Fayos, and S. L. Cohn Differential Activity of ELAV-like RNA-binding Proteins in Human Neuroblastoma J. Biol. Chem., December 27, 1996; 271(52): 33587 - 33591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. Machiels, A. H. G. Zorenc, J. M. Endert, H. J. H. Kuijpers, G. J. J. M. van Eys, F. C. S. Ramaekers, and J. L. V. Broers An Alternative Splicing Product of the Lamin A/C Gene Lacks Exon 10 J. Biol. Chem., April 19, 1996; 271(16): 9249 - 9253. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Dulcey, J. Georger Jr, V Krauthamer, D. Stenger, T. Fare, and J. Calvert Deep UV photochemistry of chemisorbed monolayers: patterned coplanar molecular assemblies Science, April 26, 1991; 252(5005): 551 - 554. [Abstract] [PDF]
|
|
|
|
|
|
M Eisinger, O Marko, S Ogata, and L. Old Growth regulation of human melanocytes: mitogenic factors in extracts of melanoma, astrocytoma, and fibroblast cell lines Science, September 6, 1985; 229(4717): 984 - 986. [Abstract] [PDF]
|
|
|
|
 |
|
 R. C. SEEGER, S. E. SIEGEL, and N. SIDELL Neuroblastoma: Clinical Perspectives, Monoclonal Antibodies, and Retinoic Acid Ann Intern Med, December 1, 1982; 97(6): 873 - 884. [Abstract] [PDF]
|
|
|
|
|
|
H. Clark Rabies viruses increase in virulence when propagated in neuroblastoma cell culture Science, March 10, 1978; 199(4333): 1072 - 1075. [Abstract] [PDF]
|
|
|
|
|
|
G Balaban-Malenbaum and F Gilbert Double minute chromosomes and the homogeneously staining regions in chromosomes of a human neuroblastoma cell line Science, November 18, 1977; 198(4318): 739 - 741. [Abstract] [PDF]
|
|
|
|
|
|
J. Biedler and B. Spengler Metaphase chromosome anomaly: association with drug resistance and cell-specific products Science, January 16, 1976; 191(4223): 185 - 187. [Abstract] [PDF]
|
|
|
|
|
|
D. A. Linseman, K. A. Heidenreich, and S. K. Fisher Stimulation of M3 Muscarinic Receptors Induces Phosphorylation of the Cdc42 Effector Activated Cdc42Hs-associated Kinase-1 via a Fyn Tyrosine Kinase Signaling Pathway J. Biol. Chem., February 16, 2001; 276(8): 5622 - 5628. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
