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Absence of Aminonucleoside-sensitive Steps in the Cell Cycle of SV40-transformed Human Fibroblasts¹

Department of Pathology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107

Puromycin aminonucleoside arrests cultured normal human lung fibroblasts in the G₁ and G₂ phases of the cell cycle but permits fibroblasts transformed by the oncogenic virus SV40 to continue their cell-cycle traverse. Aminonucleoside has no detectable effect on the entry of the transformed cells into mitosis but it does accelerate the rate of detachment of these cells from the growth surface. These differences were not due to an altered rate of penetration of the membrane of the transformed cells by amino-nucleoside.

¹ This work was supported by USPHS Research Grants CA12334-02 and CA12351-02 from the National Cancer Institute.

² Present address: Medical Research Institute, Putnam Memorial Hospital, Bennington, Vt. 05201.

³ To whom reprint requests and correspondence should be addressed.

Received 4/13/73. Accepted 7/18/73.

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