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In Vitro Binding of ⁶⁷Ga to L1210 Cells¹

Hematology-Oncology Division, Department of Medicine, and the Cancer Research and Training Center, University of Alabama in Birmingham School of Medicine, Birmingham, Alabama 35294

In vitro methods have been utilized to study ⁶⁷Ga binding to L1210 leukemic cells. Uptake of the radioisotope exhibited a striking temperature dependence, approach to saturation, accumulation within the cell, and partial irreversibility. Cell fractionation studies indicated distribution of the radioisotope among various cellular components, including soluble macromolecular binders, rather than preferential association with any specific organelle. These results demonstrate the applicability of in vitro methods to studies of the mechanism of uptake of tumor-scanning agents.

¹ This research was supported in part by USPHS Grant 5-PO2-CA-13148 from the National Cancer Institute.

Received 11/28/72. Accepted 7/23/73.