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The Response of Synchronized Human Lymphoma Cells to Bleomycin and 1,3-Bis(2-chloroethyl)-1-nitrosourea

Departments of Clinical Chemistry and Laboratory Medicine, Biomathematic and Developmental Therapeutics, The University of Texas at Houston, M. D. Anderson Hospital and Tumor Institute, Texas Medical Center, Houston, Texas 77025

Synchronized human lymphoma cells treated with bleomycin exhibited the greatest sensitivity in G₂. Doseresponse curves presented biphasic characteristics indicating the presence of sensitive and less sensitive cells in all stages of the cell cycle. Synchronized cells incubated with 1,3-bis(2-chloroethyl)-1-nitrosourea also showed the greatest sensitivity in G₂. A threshold-type dose-response survival curve was elicited in all phases of the cell cycle suggesting that damage must be accumulated before cell killing is expressed even in the sensitive stages.

Received 5/11/73. Accepted 7/19/73.