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Test for Carcinogenicity of Food Additives and Chemotherapeutic Agents by the Pulmonary Tumor Response in Strain A Mice¹

Departments of Community Medicine [G. D. S., M. B. S.] and Medicine [A. J. K.], School of Medicine, University of California, San Diego, La Jolla, California 92037; American Health Foundation, New York, New York 10021 [J. H. W.]; and Carcinogen Metabolism and Toxicology Branch [E. K. W.] and Division of Cancer Cause and Prevention [G. B. G.], National Cancer Institute, Bethesda, Maryland 20014

Forty-one food additives and 20 chemotherapeutic agents were examined for their ability to induce primary lung tumors in A mice. The animals received i.p. injections of each compound for 8 weeks and were killed at 24 weeks after the first injection. With some of the more toxic compounds, fewer injections were administered. Two or three dose levels were used for each chemical.

Cinnamyl anthranilate was the only positive of the 41 food additives tested. Safrole and sodium saccharin were negative for pulmonary tumor response under the conditions used.

Of the 20 chemotherapeutic agents, including alkylating chemicals, 12 were found to be positive in inducing pulmonary tumors. Uracil mustard was the most active compound. Myleran was inactive at the dose levels used.

¹ This research was supported by Contract 70-2206 from the National Cancer Institute.

Received 6/ 1/73. Accepted 8/23/73.

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