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Histochemical Studies on Nuclease Activity and Neoplastic Transformation in Rat Liver during Diethylnitrosamine Carcinogenesis¹

Institut du Cancer de Montréal, Hôpital Notre-Dame, and Départments de Pathologie[B. F.] et d'Anatomie [R. D.], Université de Montréal, Montréal, Canada

The distribution of RNase activity and the occurrence of hyperbasophilic foci and tumors have been examined in rat liver during diethylnitrosamine carcinogenesis.

A focal loss of RNase activity was found to occur in the hyperplastic liver nodules prior to the development of hyperbasophilic foci and hepatomas. The RNase-negative areas were widely distributed in livers of rats treated with diethylnitrosamine and so were the hyperbasophilic foci and the tumors. The results indicate that temporal and topographic correlations exist among these phenomena and suggest that a deficiency of RNase activity may play a role in the development of hyperbasophilic foci and hepatomas.

¹ This work was supported by grants from the National Cancer Institute of Canada and also by grants from La Foundation J. H. Biermans and Le Fondations J. Rhéaume.

² Postdoctoral trainee on study leave from the Laboratoire de Cytologie, Centre Léon Bérard, Lyon, France. Mailing address: Institut du Cancer de Montréal, Hôpital Notre-Dame, 1560 est rue Sherbrooke, Montréal 133, Canada.

³ Research Associate of the National Cancer Institute of Canada.

Received 3/ 8/73. Accepted 8/23/73.