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Metastasis in a Transplantable Mammotrophic Pituitary Tumor¹

Department of Pathology, State University of New York at Buffalo, Buffalo, New York 14207

Two strains of a mammotrophic pituitary tumor were compared; the secretion of adrenocorticotropic hormone had declined appreciably in one and, in the other, was unchanged. The secretion of adrenocorticotropic hormone by the pituitary tumor does not appear to be related to the capacity for metastasis inasmuch as metastasis was observed in the retroperitoneal lymph nodes of animals bearing both types of tumor. The microscopic picture as well as ultrastructure of the metastases were identical to that of the primary tumor. Metastases were not observed grossly or microscopically in any other organs. The size of the altered tumor was considerably larger than that of the unchanged one. The adrenal glands were significantly smaller in animals bearing the altered tumor, compared with those from animals bearing the unchanged tumor.

¹ Supported by Research Grant HL 06975 from the National Heart and Lung Institute.

² Present address: Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City, Kan.

³ Present address: Department of Pathology, Nagasaki University School of Medicine, Nagasaki, Japan.

Received 7/ 3/73. Accepted 8/27/73.