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Modification of Surface Topography of Lymphocytes by L-Asparaginase¹

Departments of Pathology and Microbiology, School of Dental Medicine and Center for Oral Health Research, University of Pennsylvania, Philadelphia, Pennsylvania 19174 [I. J. F., P. C. M.], and Laboratoire de Recherche sur les Tumeurs de la peau Humaine Fondation A. de Rothschild, Paris, France, [J. P. C.]

L-Asparaginase is a chemotherapeutic agent that is also immunosuppressive, inhibiting both the cellular and humoral responses. This study deals with the effects of the enzyme on lymphocyte surface receptors to the mitogen concanavalin A. We previously reported that short incubation of lymphocytes with L-asparaginase leads to a decreased binding of the mitogen to their surface. We now report that the enzyme is unable to cleave off concanavalin A surface receptors but causes a significant clustering effect on the topographic distribution of such membrane concanavalin A sites. The mechanism of immunosuppression by L-asparaginase thus appears to be due to alteration of surfaces of lymphocytes which probably accounts for its immunosuppressive activity.

¹ Supported by USPHS Grants DE 02623 and CA 12456.

Received 7/ 3/73. Accepted 9/ 5/73.