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Mechanism of Blocking by Hyperimmune Serum of Lymphocyte-mediated Cytolysis of Allogeneic Tumor Cells¹

Division of Immunology, Duke University Medical Center, Durham, North Carolina 27710

We have investigated the mechanism by which blocking antiserum inhibits lymphocyte-mediated cytolysis of allogeneic tumor cells in vitro. This analysis was made possible by our previous observation that the cytolytic reaction can be experimentally separated into binding and lytic phases. The results show directly that inhibition of lymphocyte-mediated cytolysis can be attributed to prevention of allogeneic tumor cell binding by cytotoxic lymphocytes. Blocking antiserum may also inhibit cytolysis by displacing bound lymphocytes from tumor cells prior to irreversible tumor cell damage.

¹ This investigation was supported in part by USPHS Grants TO5-GM-01678, SO4-RR-06148, and RO1-CAAI-14049.

² On leave of absence from The Weizmann Institute of Science, Rehovot, Israel.

Received 4/23/73. Accepted 9/10/73.