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Immunohistological Localization of Carcinoembryonic Antigen and Nonspecific Cross-reacting Antigen in Gastrointestinal Normal and Tumoral Tissues

Institut de Recherches Scientifiques sur le Cancer, 94800 Villejuif, France

The localization of the carcinoembryonic antigen (CEA) of gastrointestinal tumors and of the nonspecific cross-reacting antigen (NCA) was studied by immunocytological techniques in various cancerous and noncancerous digestive tissues.

NCA was found having the same centroglandular localization than CEA, in cancerous and noncancerous glands of colonic and gastric mucosae. The only difference was that NCA was detected much more often on adjacent cellular membranes.

Various patterns were observed in gastric adenocarcinomas, the most striking being the intracytoplasmic localization of CEA and NCA in signet ring cells of linitis plastica and the absence of labeling of anaplastic areas.

In noncancerous gastric mucosae, which were either peritumoral or excised for a gastric or duodenal ulcer, CEA and NCA were found only in glands having undergone an intestinal metaplasia.

Received 7/16/73. Accepted 9/10/73.