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"Flat" Morphology Induced in Cultured Transformed Cells by Polyphloroglucin Phosphate

Friedrich Miescher-Institute, P. O. Box 273, CH-4002 Basel, Switzerland

Polyphloroglucin phosphate and polyphloretin phosphate (known as inhibitors of hyaluronidase), at concentrations of 0.1 to 2 µg/ml, induced "flat" morphology within 24 to 48 hr and very low saturation density in cultured transformed mouse fibroblasts. The effect was reversible. Cells cultured in the presence of polyphloroglucin phosphate for 70 days resumed their "transformed" morphology 48 to 72 hr after removal of the drug.

Received 7/30/73. Accepted 9/14/73.

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