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Host Age Dependency of Regression of Rous Sarcomas of Chickens

Department of Animal Sciences, University of New Hampshire, Durham, New Hampshire 03824

Tumors were induced in Regional Poultry Research Laboratory line 6 chickens inoculated in the wing web with Rous sarcoma virus the Bryan high-titer strain of pseudotype, at 1, 14, and 28 days of age. Tumor regression failed to occur in chicks inoculated at 1 and 14 days of age, but an incidence of regression of 50% was observed in chicks inoculated at 28 days of age. Chick survival time postinoculation and the incidence of visceral metastases were directly related to chick age at inoculation. The age-dependent changes in the incidence of regression and metastases probably were associated with developing immunological maturity of the host.

¹ This paper is part of a thesis submitted by the senior author to the Graduate School, University of New Hampshire, 1973, in partial fulfillment of the requirements for the degree of Doctor of Philosophy.

Received 8/20/73. Accepted 9/18/73.