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Chondral Dysplasia Induced by Zirconium and Hafnium¹

Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104

Dysplasia of cartilage in the external ear of ICR and CBA/J mice was induced regularly by a single intradermal injection of zirconyl chloride. An identical response was seen following the local injection of hafnium oxychloride, whereas cartilaginous changes were not seen in control animals that were given similar injections of salts of aluminum, beryllium, cadmium, chromium, cobalt, and nickel.

¹ Support for this research was provided by the Thomas B. McCabe Fund.

Received 7/17/72. Accepted 10/20/72.