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Comparative Studies of Subcutaneous and Intradermal Leukemic Tumors in Guinea Pigs¹

Cancer Research Unit, Veterans Administration Hospital, Bronx, New York 10468

Small doses of L2C leukemic cell suspensions inoculated intradermally into strain 2 and F₁ hybrid guinea pigs induced leukemic tumors that regressed spontaneously in about 50% of animals, whereas s.c. inoculation induced uniformly generalized leukemia. Because of the behavioral differences between the s.c. and intradermal tumors, it appeared of interest to examine their comparative morphology by light and electron microscopy. Both s.c. and actively growing intradermal tumors are made up of identical nonphagocytic histiocytes and contain virus particles. They differ in the number of proliferating cells, which is larger in the s.c. tumors. Cell necrosis is a conspicuous feature of the regressing intradermal tumors and is manifested by large numbers of macrophages with engulfed lysed cells or cell fragments. The virus particles disappear before the tumors regress.

¹ Aided in part by grants from the Damon Runyon Memorial Fund, the American Cancer Society, the Virginia and D. K. Ludwig Foundation, and the Chemotherapy Foundation of New York.

Received 7/25/72. Accepted 10/20/72.

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