This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Vesselinovitch, S. D. Articles by Manojlovski, B. Search for Related Content PubMed PubMed Citation Articles by Vesselinovitch, S. D. Articles by Manojlovski, B.

Role of Hormonal Environment, Partial Hepatectomy, and Dose of Ethylnitrosourea in Renal Carcinogenesis¹

Department of Radiology, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637

For evaluation of factors modifying renal carcinogenesis, several groups of 6-week-old C57BL x C3H F₁ mice of both sexes were exposed once to 60 or 120 µg ot ethylnitrosourea per g of body weight. This treatment was preceded in some groups by partial hepatectomy and/or ovariectomy. Animals were killed at 90 weeks of age, and the incidence of renal tumors was evaluated.

Ethylnitrosourea induced papillary cystadenomas and solid granular and clear cell-type tumors. The incidence of tumors was dependent upon the dose. Sex difference was revealed in groups exposed to higher doses of ethylnitrosourea. Only the combination of partial hepatectomy and bilateral ovariectomy significantly augmented development of kidney tumors.

¹ This investigation has been supported in part by Grant 69-6 from the American Cancer Society, Illinois Division, Inc., American Cancer Society Institutional Grant ACS-IN-41-I, General Research Support Grant USPHS-5-501, Grant USPHS 5-P06-RR-00409-05 for A. J. Carlson Animal Research Facility, and USPHS, NIH-HCI Contract 69-2087.

Received 6/13/72. Accepted 11/ 3/72.

This article has been cited by other articles:

				S. Parodi, M. Taningher, P. Boero, and L. Santi Quantitative Correlation with Carcinogenic Potency of Different Short Term Tests Toxicol Pathol, April 1, 1984; 12(3): 247 - 255. [Abstract] [PDF]