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Early Effects of Glucocorticoid Treatment on Amino Acid Metabolism in Lymphosarcoma P1798¹

Research Institute of the Hospital for Joint Diseases, Mount Sinai School of Medicine, New York, New York 10035

Administration of 9-fluoroprednisolone causes an early (3 hr) decrease of basic amino acid incorporation into CS-P1798 lymphosarcoma protein. Decreased utilization of neutral amino acids is observed after 6 hr. These effects are accompanied by expansion of the intratumoral free amino acid pool in CS—but not in CR-P1798. Thus, decreased incorporation of radioactive amino acids in CS-P1798 appears to result from pool dilution of the tracers. It is suggested that the increase in intratumoral levels of free amino acids is a consequence of steroid-induced breakdown of tumor protein and that this effect may be related to tumor regression.

¹ This investigation was supported by USPHS Research Grant CA 10064 from the National Cancer Institute. Preliminary reports of this study were presented at the 62nd and 63rd Annual Meetings of the American Association for Cancer Research, Chicago (1971) and Boston (1972).

Received 10/29/71. Accepted 11/ 3/72.