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The Nature of Estrogen and Prolactin Effect on Mammary Tumorigenesis

Department of Breast Surgery and Endocrine Research Laboratory, Roswell Park Memorial Institute, Buffalo, New York 14203

Increased release of pituitary prolactin as a result of placement of electrolytic lesions in the median eminence of the hypothalamus greatly accelerated the growth rate of carcinogen-induced mammary tumors in rats. Ovariectomy in these rats induced a rapid regression of tumors in spite of high plasma levels of prolactin. Grafting a pair of ovaries into ovariectomized rats with lesions of the median eminence did not alter the levels of plasma prolactin, but it did cause a rapid resumption of tumor growth. It is concluded that the prolactin stimulus to growth of mammary tumor is dependent on the presence of ovarian hormones.

Received 10/ 3/72. Accepted 11/ 9/72.

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