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Preferential Effect of Dichlorvos (Vapona) on Bacteria Deficient in DNA Polymerase¹

Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032

Bacteria deficient in DNA polymerase are much more susceptible than are normal cells to the lethal action of dichlorvos [Vapona, O,O-dimethyl O-(2,2-dichlorovinyl) phosphate], a widely used insecticide. The results are taken to indicate that dichlorvos is capable of altering the cellular DNA.

¹ This investigation was supported by a grant from the Dr. George A. Carden, Jr. Special Fund for Cancer Research.

² Research Career Development Awardee of the National Institute of General Medical Sciences (5-K3-GM-29,024).

Received 9/ 1/72. Accepted 11/16/72.