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Rapid Uptake of Dietary Cholesterol by Hyperplastic Liver Nodules and Primary Hepatomas

Departments of Oncology and Pathology, McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706

Hyperplastic liver nodules and primary hepatomas induced by 2-acetylaminofluorene take up cholesterol-³H, given p.o., at a rate only slightly less than that in normal liver, and 10- to 30-fold greater than that reported for transplantable hepatomas. In the case of primary hepatomas, the rate of uptake appeared to be related to the degree of differentiation and hence a function of tumor progression. Previous studies on regulation of cholesterol synthesis in primary hepatomas and cholesterol uptake studies in transplantable hepatomas may need to be reinterpreted in view of these results.

¹ Damon Runyon Memorial Fund Postdoctoral Fellow.

² NIH Postdoctoral Fellow.

³ Supported in part by NIH General Research Support Grant G-374-6.

Received 9/29/72. Accepted 11/16/72.