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Reduction of Leukemia Incidence following Splenectomy in the Rat¹

Hematology Division, Department of Medicine, Peter Bent Brigham Hospital and Joint Center for Radiation Therapy, Harvard Medical School, Boston, Massachusetts 02115

Mononuclear cell leukemia occurs spontaneously in 24.2% of inbred Fischer and 17.9% of inbred Wistar Furth rats. Splenectomy at 1 and 2 months of age greatly reduced the incidence of leukemia in these animals.

¹ This investigation was supported by USPHS Grant CA-05691-05, USPHS Grant CA-10941, and the Nehemias Gorin Foundation.

Received 9/29/72. Accepted 12/11/72.

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