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Demonstration of Common Sarcoma-associated Antigen(s) in an Established Human Neurogenic Sarcoma Cell Line¹

Department of Clinical Pathology, The University of Texas at Houston, M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77025

An established human neurogenic sarcoma cell line presented a tumor-associated antigen common to various sarcoma tumors. The antigen was detected by immunofluorescent techniques with the use of the sera of patients bearing such tumors and is located mainly on the cellular surface. The tumor-specific antibody of most sera showed only membrane immunofluorescence while five sera revealed both intracytoplasmic and membrane immunofluorescence. In one case, only intracytoplasmic fluorescence was detected. Sixteen of 22 sera of patients with sarcoma gave positive reactions with antibody titers ranging from 40 to 160. Only 1 of 16 sera from patients with other neoplastic diseases and 1 serum of 18 normal sera gave positive results. The tumor antigen(s) present in this established cell line may provide an easy, standard source in the development of a clinical laboratory screening and monitoring assay for sarcoma tumors.

¹ This work was supported in part by an institutional grant of the American Cancer Society (IN43L-02).

Received 10/31/72. Accepted 12/11/72.