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Effect of Human Milk on the Mouse Mammary Tumor Virus¹

Institute for Medical Research, Camden, New Jersey 08103

Mouse mammary tumor virus when mixed with whole, skimmed, or cream fractions of some human milks and incubated at 37° for 18 hr resulted in degradation of the particle morphology and decreased infectivity and reverse transcriptase activity of the virions. The cream fraction was more effective in the physical, biochemical, and biological degradation of the virions than the whole or skimmed milk, but the nature of the degrading component(s) has not been determined. The significance of the destructive effect of human milk upon mouse mammary tumor virus in relation to our search for the putative human breast cancer virus particles and reverse transcriptase activity in human milk isolates has been discussed.

¹ This study was conducted under USPHS Contract PH 43-68-1000 within the Special Virus Cancer Program of the National Cancer Institute; Grant CA 08740 from the National Cancer Institute; General Research Support Grant FR-5582 from the Division of Research Facilities and Resources; and Grant-in-Aid M-43 from the State of New Jersey.

Received 8/25/72. Accepted 1/15/73.

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