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Response of Mammalian Cells following Treatment with Bleomycin and 1,3-Bis(2-chloroethyl)-1-nitrosourea during Plateau Phase¹

Departments of Surgery [S. C. B., J. K. N.] and Physics, [R. M. H.], The University of Texas at Houston M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77025

One hr of exposure to bleomycin (100 µg/ml) during the plateau phase caused a 10-fold greater decrease in the survival fraction of Chinese hamster ovary cells than was caused by bleomycin treatment during the exponential growth period. One hr of exposure to 1,3-bis(2-chloroethyl)-1-nitrosourea (25 µg/ml) had no effect on the survival fraction of cells treated in the exponential growth period; however, the same dose reduced the survival fraction of cells treated in plateau phase to 0.0002 (this represents a 500-fold decrease in the survival fraction).

¹ This work was supported by American Cancer Society Institutional Research Grant ACS-IN-43-L.

Received 9/ 8/72. Accepted 12/28/72.

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