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Plasma Gonadotropin Levels during Early Stages of Ovarian Tumorigenesis in Mice of the W^x/W^v Genotype¹

The Jackson Laboratory,^,3 Bar Harbor, Maine 04609

The ovaries of (C57BL/6J x C3H/HeJ) F₁-W^x/W^v mice contain few oocytes at birth, rapidly lose the follicular apparatus, and develop a 95% incidence of bilateral complex tubular adenomas by 5 months of age. Plasma levels of the pituitary gonadotropic hormones, luteinizing hormone and follicle-stimulating hormone, determined by radioimmunoassay, were significantly elevated between 30 and 210 days of age in W^x/W^v mice in comparison with congenic +/+ controls. Both hormones were increased at least 4-fold throughout the period except for luteinizing hormone, which was increased 2-fold at 30 days. Ovariectomy at 60 days of age induced the same maximum levels of luteinizing and follicle-stimulating hormones within 2 weeks in females of both genotypes. These findings provide quantitative confirmation of the hypothesis that prolonged stimulation by gonadotropic hormones induces ovarian tumors.

¹ Supported in part by NIH Research Grant CA-05985 from the National Cancer Institute, NIH Research Grants HD-05523 and HD-04083 from the National Institute of Child Health and Human Development, and a contribution from Dr. and Mrs. Clarence C. Little.

² Postdoctoral Fellow, National Cancer Institute Training Grant CA-05013.

³ Fully accredited by the American Association for Accreditation of Laboratory Animal Care.

Received 12/11/72. Accepted 1/ 5/73.

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