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Induction by Dimethylhydrazine of Intestinal Carcinoma in Normal Rats and Rats Fed High or Low Levels of Vitamin A¹

Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Induction of intestinal tumors by intragastric administration of 1,2-dimethylhydrazine (DMH) was studied in rats fed a semisynthetic diet containing either high, adequate, or low levels of vitamin A. Sixty to 100% of the treated rats had intestinal carcinoma 6 months after administration of the first dose of DMH. Total doses in amounts ranging from 195 to 420 mg/kg did not affect tumor incidence; however, rats given the largest total dose in the largest individual doses (30 mg/kg) developed more tumors in the colon than in other sites. Tumors were polypoid or intramural adenocarcinomas, of which a variable number produced mucus. In many cases they caused passage of bloody stools, intestinal obstruction, and/or intussusception. Tumor incidence and morphology were in all ways comparable to those reported in studies in which DMH was administered s.c. A high level of vitamin A in the diet (sufficient to raise the vitamin content in the serum and liver and reduce growth) did not change the incidence of colon tumors but decreased the number of tumors per rat at the highest DMH dose. Chronic dietary deficiency of vitamin A increased the incidence of tumors slightly and may have reduced induction time.

¹ This research was supported by Grant 5-PO1-ES00597-92 from the NIH and by a grant from the William S. Merrell Company, Cincinnati, Ohio.

Received 11/30/72. Accepted 2/ 2/73.

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