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Lysosomal Hyaluronidase Activity in Normal Rat Liver and in Chemically Induced Hepatomas

Fondation Curie, Institut du Radium, Bâtiment 111, 91405-Orsay, France

It has been demonstrated that solid hepatoma lysosomes lack hyaluronidase activity, whereas normal rat liver lysosomes contain a high level of this enzyme. This result was also found with lysosomes from an ascites hepatoma, Walker carcinoma 256, and virally transformed BHK cells.

In contrast, ß-N-acetylglucosaminidase activity was shown to be present in lysosomes from tumor cells, although its level was decreased by about 75%, compared with that of controls. As it is known that hyaluronidase and ß-N-acetylglucosaminidase activities are increased in the extracellular space of tumors, we suggest that the lack of hyaluronidase and the important decrease of ß-N-acetylglucosaminidase in tumor lysosomes are due to a perturbation of the control of enzyme distribution from the Golgi apparatus to the lysosomes and the extracellular space.

¹ Supported in part by a grant from the Lady Tate Memorial Trust (London, England).

Received 11/ 5/71. Accepted 2/15/73.

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