| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Memorial Sloan-Kettering Cancer Center, New York, New York 10021, and the Cornell University Medical College, New York, New York 10021
Thirty-four CF1 mice were given weekly s.c. injections of 20 mg of 1,2-dimethylhydrazine hydrochloride per kg; this treatment induced colonic carcinomas in more than 90% of the animals after 186 days. The earliest change was found to be a widening of the proliferative compartment within the colonic crypts; at a later stage, there was an increase of the tritiated thymidine-labeling index from 9.3% at Day 45 to 16.2% at Day 87. The first histological changes were focal hyperplastic changes and focal atypias on the tip of the folds of the distal colonic mucosa (Day 38) confined to single crypts. The colonic tumors were located in the distal colon and rectum, with a high incidence of squamous cell cancers originating from the anal canal. Saline extracts of colonic tumor material precipitated specific antimouse embryonic rabbit serum. Assays of hypoxanthine phosphoribosyltransferase in the villus fraction of the small bowel of the 1,2-dimethylhydrazine hydrochloride-treated tumor-carrier mice indicated lower activity, compared to that of controls.
1 This work was supported in part by National Cancer Institute Grants Ca 08748 and 08921, Contract 72-2041, and a Swiss National Fund Fellowship. Presented in abstract form at the 63rd Meeting of the American Association for Cancer Research, May 1972.
2 Present address: Mediz. Universitatsklinik, Basel, Switzerland.
3 To whom correspondence should be addressed, at the Sloan-Kettering Institute for Cancer Research, New York, N. Y. 10021.
Received 10/12/72. Accepted 1/24/73.
This article has been cited by other articles:
![]() |
J Thulesen, B Hartmann, K J Hare, H Kissow, C Orskov, J J Holst, and S S Poulsen Glucagon-like peptide 2 (GLP-2) accelerates the growth of colonic neoplasms in mice Gut, August 1, 2004; 53(8): 1145 - 1150. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Colussi, S. Fiumicino, A. Giuliani, S. Rosini, P. Musiani, C. Macri, C. S. Potten, M. Crescenzi, and M. Bignami 1,2-Dimethylhydrazine-Induced Colon Carcinoma and Lymphoma in msh2-/- Mice J Natl Cancer Inst, October 17, 2001; 93(20): 1534 - 1540. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Kozoni, G. Tsioulias, S. Shiff, and B. Rigas The effect of lithocholic acid on proliferation and apoptosis during the early stages of colon carcinogenesis: differential effect on apoptosis in the presence of a colon carcinogen Carcinogenesis, May 1, 2000; 21(5): 999 - 1005. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. E. Jackson, D. P. Cooper, P. J. O'Connor, and A. C. Povey The relationship between 1,2-dimethylhydrazine dose and the induction of colon tumours: tumour development in female SWR mice does not require a K-ras mutational event Carcinogenesis, March 1, 1999; 20(3): 509 - 513. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. L. Saxton, D. L. Longo, H. E. Wetzel, H. Tribble, W. G. Alvord, L. W. Kwak, A. S. Leonard, C. D. Ullmann, B. D. Curti, and A. C. Ochoa Adoptive Transfer of Anti-CD3-Activated CD4+ T Cells Plus Cyclophosphamide and Liposome-Encapsulated Interleukin-2 Cure Murine MC-38 and 3LL Tumors and Establish Tumor-Specific Immunity Blood, April 1, 1997; 89(7): 2529 - 2536. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Corasanti, G. Hobika, and G Markus Interference with dimethylhydrazine induction of colon tumors in mice by epsilon-aminocaproic acid Science, May 28, 1982; 216(4549): 1020 - 1021. [Abstract] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |