This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Yakar, D. Articles by Freeman, A. Search for Related Content PubMed PubMed Citation Articles by Yakar, D. Articles by Freeman, A.

Clinical Pharmacological Trial of Guanazole¹

Departments of Medicine A [D. Y., J. F. H., R. R. E.] and Pediatrics [A. F.], Roswell Park Memorial Institute, Buffalo, New York 14203

Guanazole was given to 27 patients with advanced neoplastic diseases, mostly acute leukemia, by continuous i.v. infusion in 5-day courses. Toxicity was manifest mainly by myelosuppression, but drug fever, mucositis, rash, and alkalosis were also observed.

Complete remission was achieved in two out of 14 patients with previously treated acute myelocytic leukemia, and an M1 marrow occurred in one out of four patients with advanced acute lymphocytic leukemia. Most of the effects of guanazole appear to be dose related, with a narrow therapeutic index. This is the first evidence of therapeutic activity of guanazole in man.

¹ This investigation was supported by USPHS Research Grants CA-2599, CA-5834, and CA-07918 from the National Cancer Institute.

Received 12/29/71. Accepted 1/31/73.