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Inhibition of Ribonucleotide Reductase from Ehrlich Tumor Cells by RNA¹

Departments of Medical Microbiology and Chemistry, University of South Florida, Tampa, Florida 33620

Ribonucleotide reductase activity from Ehrlich ascites cells was inhibited by RNA. Inhibition of cytidine 5'-diphosphate reduction was observed with Ehrlich tumor cell transfer RNA, ribosomal RNA, yeast transfer RNA, and synthetic polycytidylate. Polyguanylate and polyuridylate were only slightly effective as inhibitors, while polyadenylate did not inhibit at all. The RNA's and polycytidylate appeared to be competitive inhibitors with respect to cytidine 5'-diphosphate as substrate. Adenosine 5'-diphosphate reduction was inhibited by transfer RNA but was only slightly inhibited by polyadenylate.

¹ This work was supported by Grant CA-10380 from the USPHS, National Cancer Institute.

² Recipient of Research Career Development Award CA-17199 from USPHS, National Cancer Institute.

Received 7/21/72. Accepted 2/ 2/73.