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Potentiation of Rifampicin, Rifampicin Analogs, and Tetracycline against Animal Cells by Amphotericin B and Polymyxin B¹

Divisions of Infectious Diseases [G. M.] and Dermatology [G. S. K.], Department of Medicine, and Department of Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110

The membrane-active antibiotics amphotericin B and polymyxin B enhanced the action of rifampicin, rifampicin analogs, and tetracycline against macromolecular synthesis and growth of mouse L-cells, human HeLa cells, and KB cells in tissue culture. The specificities of the second agents were maintained in that rifampicin inhibited RNA synthesis and tetracycline inhibited protein synthesis.

¹ Supported by USPHS Research Grants 1 RO1 AI 10622, AI 06213, and CA-125602-1 and by Training Grant AM 05611 and a grant from the John A. Hartford Foundation, Inc.

Received 12/18/72. Accepted 2/19/73.

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				G. Medoff and G. S. Kobayashi Amphotericin B: Old Drug, New Therapy JAMA, May 12, 1975; 232(6): 619 - 620. [Abstract] [PDF]