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Coenzymes Q Levels in Liver, Spleen, and Blood of Mice with Friend Leukemia Virus Infection¹

New England Institute, Ridgefield, Connecticut 06877

The coenzymes Q levels of blood, spleen, and liver of mice infected with Friend leukemia virus were compared with those of control groups at 10, 20, 30, and 40 days after infection. A significant increase in the total coenzymes Q level in the blood was observed. This increase reaches about fivefold the normal level, 30 days after the infection. The total coenzymes Q concentration in the liver does not change appreciably, but the relative concentration of coenzyme Q₁₀ begins to increase 10 days after infection. No change in coenzymes Q level or in the homolog present was observed in the spleen of the infected mice.

¹ This investigation investigation was supported by research grants from Arca Foundation (formerly Reynolds Bagley Verney Foundation); The John A. Hartford Foundation, Inc.; Heddens-Good Foundation; Virginia and D. K. Ludwig Foundation, Inc.; J. M. McDonald Foundation; Henry Nias Foundation, Inc.; Elsa U. Pardee Foundation; Fannie E. Rippel Foundation; Damon Runyon Memorial Fund for Cancer Research, Inc. (Grant DRG-1098); Scaife Family of Pittsburgh; The Sears Family Foundation; Wallace Genetic Foundation; The Raymond J. Wean Foundation; and Whitehall Foundation, Inc.

Received 12/19/72. Accepted 2/27/73.

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