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Viropexis of Type B Particles in Reticulum Cell Sarcoma of RIII/Dm Strain Mice¹

Department of Virology, The University of Texas at Houston M. D. Anderson Hospital and Tumor Institute, Texas Medical Center, Houston, Texas 77025

Results of ultrastructural studies of generalized reticulum cell sarcomas in virgin RIII/Dm strain female mice with transplants of isologous embryo tissues are presented. The spleen tumors contained numerous type B and type C virus particles and, in smaller numbers, intracytoplasmic type A virus particles. Budding of virus particles was frequently seen. In the spleen tumors, type B virus particles were seen adsorbed on the plasma membrane of the reticulum tumor cells and penetrating into the cytoplasm of the cells by a mechanism described as viropexis. Nucleoids of the virions were apparently released in the cytoplasm of the tumor cells. Both type B and type C particles were phagocytized by macrophages in the spleen tumors. Adsorption of type B particles, budding of type C particles, and intracytoplasmic type A particles were observed in the same tumor cells. Type C particles and budding of type C particles, but not type B particles, were also seen in the lymph nodes and the intrathoracic tumors of these mice. Type B particles and their behavior in reticulum cell sarcoma of mice have not been previously recorded.

¹ Supported in part by USPHS Contract PH 43-NCI-E-65-604 within the Special Virus Cancer Program of the National Cancer Institute and in part by Grants CA-05831 and RR-05511 from the National Cancer Institute, NIH, USPHS.

Received 12/29/72. Accepted 3/ 5/73.

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