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Cytohistopathology of Cervical Cancer¹

Division of Epidemiology, School of Public Health, University of California at Los Angeles, Los Angeles, California 90024

Proceeding from an account of the development, structure, and function of the uterine cervix, the cytology and histology of cancer of the cervix is presented by stage of the disease. The concept of biological progression in the pathogenesis of cancer of the cervix is utilized to consider a gradient of changes in the endocervical mucosa: reserve cell hyperplasia and squamous metaplasia as preliminary nonspecific modifications; dysplasia as a cancer precursor; and the preinvasive and invasive stages of cancer.

¹ Presented at the American Cancer Society Conference on Herpesvirus and Cervical Cancer, December 8 to 10, 1972, Key Biscayne. Fla. Assistance was obtained from the UCLA Health Sciences Computing Facility, sponsored by NIH Grant RR-3. This research is supported by the National Institute of Child Health and Development.

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				E Stern, A. Forsythe, L Youkeles, and C. Coffelt Steroid contraceptive use and cervical dysplasia: increased risk of progression Science, June 24, 1977; 196(4297): 1460 - 1462. [Abstract] [PDF]