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Skeletal Location of Radiation-induced and Naturally Occurring Osteosarcomas in Man and Dog¹

Radiobiology Division, Anatomy Department, University of Utah, Salt Lake City, Utah 84112 [G. B. T., C. W. M., G. N. T.]; Radiological Physics Division, Argonne National Laboratory, Argonne, Illinois 60439 [A. T. K.]; and Department of Morbid Anatomy, Institute of Orthopaedics, 234 Great Portland Street, London W1, England [H. A. S.]

A compilation of six major studies on the classification of naturally occurring and radiation-induced human and canine bone sarcomas showed that osteosarcoma was the most frequent type of bone sarcoma. The skeletal distribution of osteosarcomas induced by bone-seeking radionuclides in man and dogs was different from the distribution of naturally occurring osteosarcomas.

¹ Portions of this study were financed by: Atomic Energy Commission Contract AT (11-1-119) and NIH Predoctoral Fellowship (5-F01-GM-38-740).

² Present address: Division of Biochemistry, Department of Human Biological Chemistry and Genetics, The University of Texas Medical Branch, Galveston, Texas 77550.

Received 7/17/72. Accepted 3/23/73.