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Variations in Extent of Aryl Hydrocarbon Hydroxylase Induction in Cultured Human Lymphocytes¹

Section of Medical Genetics, Department of Biology, The University of Texas, M. D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas 77025

Induction of aryl hydrocarbon hydroxylase in cultured human lymphocytes by 3-methylcholanthrene was determined for 103 healthy unrelated adults. The ratio of 3-methylcholanthrene-treated to control cells, a measure of induction, ranged from 1.4 to 5.6 among this population, and the value for each individual was constant under different culture conditions and was highly reproducible. At least two groups can be identified with respect to extent of induction. The results suggest that the capacity for aryl hydrocarbon hydroxylase induction in man is genetically determined. Implications for susceptibility to chemical carcinogenesis are discussed.

¹ This work was supported in part by NIH Research Grant GM 15597 and Grant Ke 217/1 Deutsche Forschungsgemeinschaft.

Received 12/11/72. Accepted 4/ 5/73.