Cancer Research Infection and Cancer: Biology, Therapeutics, and Prevention 09 AM Call for Abstracts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 33, 1829-1836, August 1, 1973]
© 1973 American Association for Cancer Research
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sasaki, M. S.
Right arrow Articles by Tonomura, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sasaki, M. S.
Right arrow Articles by Tonomura, A.

A High Susceptibility of Fanconi's Anemia to Chromosome Breakage by DNA Cross-linking Agents1

Masao S. Sasaki and Akira Tonomura

Department of Human Cytogenetics, Institute for Medical Genetics, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo 113, Japan

Peripheral blood lymphocytes of patients with Fanconi's anemia (FA) were tested for their susceptibility to chromosome breakage by caffeine, chloramphenicol, actinomycin D, methylmethanesulfonate, nitrogen mustard, mitomycin C, decarbamoyl mitomycin C, N-methyl-N'-nitro-N-nitrosoguanidine, 4-nitroquinoline 1-oxide, 8-methoxypsoralen, and 60Co {gamma}-ray and ultiviolet irradiations. A definitely abnormal response of the chromosomes of the FA cells was found when they were treated with nitrogen mustard and mitomycin C and after the irradiation with long-wavelength ultraviolet light in the presence of 8-methoxypsoralen. The specifically increased susceptibility to these compounds, which can introduce interstrand cross-links into DNA, is interpreted as an indication that the FA cells are defective in the repair mechanism to tolerate the cross-links produced in their DNA. The impairment of the capacity to tolerate the lesions produced in DNA may be implicated in the increased risk to develop malignant neoplasms in this hereditary disorder.

1 This work was supported by grants from the Ministry of Education of Japan.

Received 12/27/72. Accepted 4/16/73.




This article has been cited by other articles:


Home page
 MutagenesisHome page
A. Mohseni-Meybodi, H. Mozdarani, and S. Mozdarani
DNA damage and repair of leukocytes from Fanconi anaemia patients, carriers and healthy individuals as measured by the alkaline comet assay
Mutagenesis, October 3, 2008; (2008) gen052v1.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Briot, G. Mace-Aime, F. Subra, and F. Rosselli
Aberrant activation of stress-response pathways leads to TNF-{alpha} oversecretion in Fanconi anemia
Blood, February 15, 2008; 111(4): 1913 - 1923.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
M. Mechilli, A. Schinoppi, K. Kobos, A. T. Natarajan, and F. Palitti
DNA repair deficiency and acetaldehyde-induced chromosomal alterations in CHO cells
Mutagenesis, January 1, 2008; 23(1): 51 - 56.
[Abstract] [Full Text] [PDF]

Home page
 haematolHome page
M. A. Dimopoulos, V. L. Souliotis, A. Anagnostopoulos, C. Bamia, A. Pouli, I. Baltadakis, E. Terpos, S. A. Kyrtopoulos, and P. P. Sfikakis
Melphalan-induced DNA damage in vitro as a predictor for clinical outcome in multiple myeloma
Haematologica, November 1, 2007; 92(11): 1505 - 1512.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
S. Seki, M. Ohzeki, A. Uchida, S. Hirano, N. Matsushita, H. Kitao, T. Oda, T. Yamashita, N. Kashihara, A. Tsubahara, et al.
A requirement of FancL and FancD2 monoubiquitination in DNA repair
Genes Cells, March 1, 2007; 12(3): 299 - 310.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Kitao, K. Yamamoto, N. Matsushita, M. Ohzeki, M. Ishiai, and M. Takata
Functional Interplay between BRCA2/FancD1 and FancC in DNA Repair
J. Biol. Chem., July 28, 2006; 281(30): 21312 - 21320.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Mankad, T. Taniguchi, B. Cox, Y. Akkari, R. K. Rathbun, L. Lucas, G. Bagby, S. Olson, A. D'Andrea, and M. Grompe
Natural gene therapy in monozygotic twins with Fanconi anemia
Blood, April 15, 2006; 107(8): 3084 - 3090.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
S. Houghtaling, A. Newell, Y. Akkari, T. Taniguchi, S. Olson, and M. Grompe
Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining
Hum. Mol. Genet., October 15, 2005; 14(20): 3027 - 3033.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
Y.-G. Yang, Z. Herceg, K. Nakanishi, I. Demuth, C. Piccoli, J. Michelon, G. Hildebrand, M. Jasin, M. Digweed, and Z.-Q. Wang
The Fanconi anemia group A protein modulates homologous repair of DNA double-strand breaks in mammalian cells
Carcinogenesis, October 1, 2005; 26(10): 1731 - 1740.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. Yamamoto, S. Hirano, M. Ishiai, K. Morishima, H. Kitao, K. Namikoshi, M. Kimura, N. Matsushita, H. Arakawa, J.-M. Buerstedde, et al.
Fanconi Anemia Protein FANCD2 Promotes Immunoglobulin Gene Conversion and DNA Repair through a Mechanism Related to Homologous Recombination
Mol. Cell. Biol., January 1, 2005; 25(1): 34 - 43.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Ishiai, M. Kimura, K. Namikoshi, M. Yamazoe, K. Yamamoto, H. Arakawa, K. Agematsu, N. Matsushita, S. Takeda, J.-M. Buerstedde, et al.
DNA Cross-Link Repair Protein SNM1A Interacts with PIAS1 in Nuclear Focus Formation
Mol. Cell. Biol., December 15, 2004; 24(24): 10733 - 10741.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. R. Schoenfeld, S. Apgar, G. Dolios, R. Wang, and S. A. Aaronson
BRCA2 Is Ubiquitinated In Vivo and Interacts with USP11, a Deubiquitinating Enzyme That Exhibits Prosurvival Function in the Cellular Response to DNA Damage
Mol. Cell. Biol., September 1, 2004; 24(17): 7444 - 7455.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. S. Van der Heijden, J. R. Brody, E. Gallmeier, S. C. Cunningham, D. A. Dezentje, D. Shen, R. H. Hruban, and S. E. Kern
Functional Defects in the Fanconi Anemia Pathway in Pancreatic Cancer Cells
Am. J. Pathol., August 1, 2004; 165(2): 651 - 657.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
S. L. Donahue and C. Campbell
A Rad50-dependent pathway of DNA repair is deficient in Fanconi anemia fibroblasts
Nucleic Acids Res., June 15, 2004; 32(10): 3248 - 3257.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. Rothfuss and M. Grompe
Repair Kinetics of Genomic Interstrand DNA Cross-Links: Evidence for DNA Double-Strand Break-Dependent Activation of the Fanconi Anemia/BRCA Pathway
Mol. Cell. Biol., January 1, 2004; 24(1): 123 - 134.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Pipaon, J. A. Casado, J. A. Bueren, and J. L. Fernandez-Luna
Jun N-terminal kinase activity and early growth-response factor-1 gene expression are down-regulated in Fanconi anemia group A lymphoblasts
Blood, January 1, 2004; 103(1): 128 - 132.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. Yamamoto, M. Ishiai, N. Matsushita, H. Arakawa, J. E. Lamerdin, J.-M. Buerstedde, M. Tanimoto, M. Harada, L. H. Thompson, and M. Takata
Fanconi Anemia FANCG Protein in Mitigating Radiation- and Enzyme-Induced DNA Double-Strand Breaks by Homologous Recombination in Vertebrate Cells
Mol. Cell. Biol., August 1, 2003; 23(15): 5421 - 5430.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. W. Lensch, M. Tischkowitz, T. A. Christianson, C. A. Reifsteck, S. A. Speckhart, P. M. Jakobs, M. E. O'Dwyer, S. B. Olson, M. M. Le Beau, S. V. Hodgson, et al.
Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia
Blood, July 1, 2003; 102(1): 7 - 16.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Ikeda, M. Matsushita, Q. Waisfisz, A. Kinoshita, A. B. Oostra, A. W. M. Nieuwint, J. P. de Winter, M. E. Hoatlin, Y. Kawai, M. S. Sasaki, et al.
Genetic Reversion in an Acute Myelogenous Leukemia Cell Line from a Fanconi Anemia Patient with Biallelic Mutations in BRCA2
Cancer Res., May 15, 2003; 63(10): 2688 - 2694.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
P. Pichierri, D. Averbeck, and F. Rosselli
DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein
Hum. Mol. Genet., October 2, 2002; 11(21): 2531 - 2546.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. Digweed, S. Rothe, I. Demuth, R. Scholz, D. Schindler, M. Stumm, M. Grompe, A. Jordan, and K. Sperling
Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia
Carcinogenesis, July 1, 2002; 23(7): 1121 - 1126.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
M. Koomen, N. C. Cheng, H. J. van de Vrugt, B. C. Godthelp, M. A. van der Valk, A. B. Oostra, M. Z. Zdzienicka, H. Joenje, and F. Arwert
Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice
Hum. Mol. Genet., February 1, 2002; 11(3): 273 - 281.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
M. Grompe and A. D'Andrea
Fanconi anemia and DNA repair
Hum. Mol. Genet., October 1, 2001; 10(20): 2253 - 2259.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
K. R. Kumaresan and M. W. Lambert
Fanconi anemia, complementation group A, cells are defective in ability to produce incisions at sites of psoralen interstrand cross-links
Carcinogenesis, April 1, 2000; 21(4): 741 - 751.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
G. Speit, P. Schutz, and O. Merk
Induction and repair of formaldehyde-induced DNA-protein crosslinks in repair-deficient human cell lines
Mutagenesis, January 1, 2000; 15(1): 85 - 90.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
D. W. Brois, L. W. McMahon, N. I. Ramos, L. M. Anglin, C. E. Walsh, and M. W. Lambert
A deficiency in a 230 kDa DNA repair protein in Fanconi anemia complementation group A cells is corrected by the FANCA cDNA
Carcinogenesis, September 1, 1999; 20(9): 1845 - 1853.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1973 by the American Association for Cancer Research.