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Xenotransplantation of Established Human Endometrial Cells into Newborn Hamsters

Department of Obstetrics and Gynecology, and Pathology Section, Central Laboratories, Okayama University Medical School, Okayama 700, Japan

A human cell line derived from a nonmalignant endometrium can produce tumors when inoculated into newborn hamsters i.p. In addition to the epithelial cells that were originally transplanted, the tumors also contained bone marrow; their origins were investigated using isozyme patterns by glucose 6-phosphate dehydrogenase. This observation indicates that xenotransplantation of human cells accompanied by ossification in nonimmunosuppressed hamsters is not a unique phenomenon seen only in the prostatic cells as Richman reported.

Received 1/31/73. Accepted 4/25/73.