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The Principal Liver Carcinogen-Protein Conjugate after a Single Dose of Hepatic Azocarcinogen¹

The Institute for Cancer Research, Fox Chase Center for Cancer and Medical Sciences, Philadelphia, Pennsylvania 19111

Two days after a single intragastric dose of the hepatic carcinogen, 3'-methyl-4-dimethylaminoazobenzene, the principal azoprotein in rat liver cytosol was the relatively basic slow h₂-5S azoprotein. The principal species of azoprotein at 2 days was the same as that previously found after azocarcinogen was fed for 2.5 through 11 weeks. Apparently, the same one liver protein serves as the principal protein target of azocarcinogen throughout most of the duration of the liver carcinogenesis.

¹ Supported in part by NIH Grants CA-05945 and C-5598, Grant E-73 from the American Cancer Society, and an appropriation from the Commonwealth of Pennsylvania.

Received 2/ 8/73. Accepted 5/ 9/73.