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Protective Effect of Benzoflavone and Estrogen against 7,12-Dimethylbenz(a)anthracene- and Aflatoxin-induced Cytotoxicity in Cultured Liver Cells¹

Fels Research Institute and Department of Microbiology, Temple University Medical School, Philadelphia, Pennsylvania 19140

7,8-Benzoflavone, a competitive inhibitor of polycyclic hydrocarbon hydroxylation, protects cultured liver cells against the cytotoxicity of aflatoxin B₁ and sterigmatocystin. Estrogenic steroids, which have previously been shown to protect against the cytotoxic effect of 7,12-dimethylbenz(a)anthracene, also protect against the cytotoxic effect of aflatoxin B₁. The possible relationship of this protective effect of estrogens to human clinical and epidemiological data is discussed.

¹ This investigation was supported by Grants CA-14661 from the NIH, Grant IN-88 from the American Cancer Society, and by General Research Support, Temple University Medical School.

Received 5/29/73. Accepted 9/21/73.