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A Comparison of Three in Vivo Assays for Cell Tumorigenicity¹

Division of Pathology, Bureau of Biologics, Food and Drug Administration, Rockville, Maryland 20852, and Lederle Laboratories, Pearl River, New York 10965

The cortisonized adult hamster, the antithymocyte-treated newborn hamster, and the antithymocyte globulin-treated monkey were compared as in vivo test systems for the tumorigenic potential of cells. The newborn hamster and monkey systems were more consistent in allowing the expression of tumors than was the cortisonized hamster when each of three human tumor cell lines was assayed. Cells derived from normal tissues failed to show evidence of tumorigenicity in any of the three animal systems.

¹ This work was supported in part by Contracts NIH-69-100 and NIH-69-2264 from Bureau of Biologics, Food and Drug Administration.

Received 2/15/73. Accepted 10/ 1/73.

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