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Radiation-induced Changes in Established Tumor Immunity¹

Department of Radiation Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114

The effect of radiation therapy on tumor growth and on specific immune resistance to tumor growth was investigated in mice actively sensitized to a syngeneic sarcoma. While radiation was therapeutic for tumor growth in the radiated field, it was also found that extensive-field radiation, but not limited-field radiation, could facilitate the growth of tumors in unradiated parts of the animal. The facilitation was greatest with radiation soon after the time of tumor implantation.

¹ This work was supported in part by USPHS Grants CA05047, CA11138, and CA13018 and by a Cancer Research Scholar Award from the American Cancer Society, Massachusetts Division. This work was begun at the University of Texas M. D. Anderson Hospital and Tumor Institute and completed at the Massachusetts General Hospital.

² Present address: Pondville Hospital, Walpole, Mass. 02081 and Department of Medicine, Tufts University, School of Medicine, Boston, Mass. 02111.

Received 7/30/73. Accepted 9/26/73.