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Leukemoid Reaction in BALB/c Mice Bearing Transplanted Tumors¹

Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan

During the growth of 10 lines of BALB/c tumors that were transplanted into BALB/cMk mice, 9 methylcholanthrene-induced fibrosarcomas (CMT-1 -9), a spontaneously developed fibrosarcoma (CST-1), leukemoid reactions characterized by an increase in the number of granulocytes in peripheral blood, and splenomegaly were observed. The leukemoid reactions were also induced in BALB/cMk x C57BL/6 F₁ mice (hereafter called CBF₁) by the transplantation of these BALB/c tumors. CBF₁ mice bearing 5 transplanted lines of methylcholanthrene-induced fibrosarcomas (BMT-1 -5) in C57BL/6 mice had the same leukemoid reaction as found in mice of the same strain bearing BALB/c tumors. However, no such reactions were induced by the transplantation of these C57BL/6 tumors into the original C57BL/6 mice. Neither C57BL/6 nor CBF₁ mice inoculated with spontaneously developed Ca755 mammary carcinoma, B-16 melanoma, and C1498 leukemia of C57BL/6 tumors showed the reaction. Furthermore, neither Ehrlich tumor nor Sarcoma 180 could induce the leukemoid reaction in BALB/cMk, C57BL/6, and CBF₁ mice. The relationship of these results to the possible tumor and host factors influencing the occurrence of the reaction is discussed.

¹ This work was supported in part by a research grant for cancer research from Ministry of Education of Japan.

Received 7/16/73. Accepted 10/ 3/73.