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The Relationship of Lysozyme to the Nephropathy in Chloroleukemic Rats and the Effects of Lysozyme Loading on Normal Rat Kidneys¹

Institute of Cancer Research and Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032

The Shay chloroleukemia in Wistar/Furth rats has been shown to produce large amounts of lysozyme (LZM) which accumulates in the kidneys and is eventually excreted in the urine. The proximal tubule cells of the tumor-bearing animals develop large complex cytoplasmic droplets containing the residua of degenerated membranes. Using specific anti-rat LZM and the immunoperoxidase method, increased amounts of LZM can be demonstrated in these tubules. Intraaortic injections of rat LZM into normal rats failed to fully reproduce these structural abnormalities, indicating the probability of other contributory factors to the nephropathy in the chloroleukemic animals.

¹ Studies supported by Grant CA-02332 of the National Cancer Institute.

² Present address: Fourth Department of Medicine, University of Helsinki, Helsinki, Finland.

³ Present address: Veterans Administration Hospital, Tampa, Fla.

⁴ Present address: Department of Internal Medicine, Third Division, Kobe University, Kobe, Japan.

⁵ Present address: Department of Medicine, Northwestern University School of Medicine, Chicago, Ill.

⁶ American Cancer Society Professor of Medicine; to whom requests for reprints should be sent.

Received 7/26/73. Accepted 9/24/73.

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