This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hashmi, S. Articles by Miller, O. J. Search for Related Content PubMed PubMed Citation Articles by Hashmi, S. Articles by Miller, O. J.

Chromosomal Heterogeneity in the RAG and MSWBS Mouse Tumor Cell Lines¹

Departments of Human Genetics and Development and Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, and Department of Tumor Biology, Karolinska Institutes, Stockholm, Sweden

By means of a Q-banding technique, virtually every chromosome in two heteroploid mouse cell lines, RAG and MSWBS, has been identified. The origin of 60 to 80% of the chromosomes has been established; the remaining chromosomes can be identified as markers characteristic of the cell line.

The extent of chromosome heterogeneity has been examined and compared in these two mouse tumor cell lines. Each line is remarkably heterogeneous and, even within a line, cells with the same total chromosome number have karyotypes that differ considerably. There are distinctive differences in the chromosomal makeup of the two lines.

¹ This work was supported in part by Grant CA 12504 from the National Cancer Institute, Grant GM 18153 from the National Institute for General Medical Sciences, and by grants from the National Foundation-March of Dimes and the Swedish Cancer Society.

² Present address: Memorial University, St. John's, Newfoundland, Canada.

Received 8/ 6/73. Accepted 10/ 1/73.