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Time Course of Tissue Water Proton Spin-Lattice Relaxation in Mice Developing Ascites Tumors¹

Johnson Research Foundation, University of Pennsylvania, Philadelphia, Pennsylvania 19174

Tissue water proton spin-lattice relaxation time (T₁) measurements of blood serum and liver homogenate were determined at various times after Ehrlich-Lettré ascites and dead ascites cell inoculation of mice. T₁ of both blood serum and liver homogenate of animals inoculated with live or dead cancer cells increased above control values. The blood serum T₁ reflected differences between the cancer-developing animals and those receiving the dead cells more distinctly than did the liver T₁. There was a 14 to 19% increase of blood serum T₁ 1 day after live or dead cancer cell inoculation of animals. Blood serum T₁ from ascites-developing mice was significantly greater (16 to 18%) than that from controls during the period 3 to 5 days after inoculation. This was not as apparent in animals inoculated with dead ascites cells. Our results demonstrate that cancer development is sufficient to induce T₁ changes; however, it is not necessarily the only condition that will induce these modifications.

¹ This study was supported by Grant GM 12202 of the USPHS, National Institutes of Health.

² Permanent address: Center Biology Natural Systems, Washington University, St. Louis, Mo. 63130.

Received 6/ 1/73. Accepted 10/ 4/73.

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