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Inhibitory Effect of Manganese upon Muscle Tumorigenesis by Nickel Subsulfide¹

Department of Laboratory Medicine, University of Connecticut School of Medicine, Farmington, Connecticut 06032

Fischer rats in five experimental groups were given a single i.m. injection of penicillin suspension containing carcinogenic Ni₃S₂ dust (2.5 mg), alone or in combination with equimolar amounts of aluminum, copper, chromium, or manganese dusts. Rats in five control groups were treated identically, except that the Ni₃S₂ dust was omitted. After 24 months, the incidence of sarcomas at the injection site was 63% in the group that received the combination of Ni₃S₂ and manganese dusts, compared with incidences of 96 to 100% in the groups that received Ni₃S₂ alone or in combination with aluminum, copper, or chromium dusts (p < 0.001). No sarcomas occurred at the injection site in control groups that did not receive Ni₃S₂. The finding that the addition of equimolar amounts of manganese dust to Ni₃S₂ dust significantly depresses Ni₃S₂-induced tumorigenesis provides an experimental system for investigations of metal interactions in carcinogenesis.

¹ Sponsored by Research Grants EHS C 0109, HSM-99-72-24 from the National Institute for Occupational Safety and Health, and AT(11-1)-3140 from the Atomic Energy Commission.

² To whom requests for reprints should be addressed, at P. O. Box G, Farmington, Conn. 06032.

³ Formerly with the National Institute for Occupational Safety and Health, Cincinnati, Ohio 45201.

Received 7/ 9/73. Accepted 10/ 8/73.

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