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Dietary Enhancement of Nitrosamine Carcinogenesis¹

Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Previous studies have shown that a diet high in fat and marginally deficient in lipotropes enhances aflatoxin B₁ hepatocarcinogenesis and depresses hepatic drug metabolism in rats. In this study we have compared induction of tumors by N-nitrosodimethylamine, N-nitrosodiethylamine, or N-nitrosodibutylamine in normal or marginally lipotrope-deficient rats fed a high-fat diet. The deficiency significantly enhanced hepatocarcinogenesis by both N-nitrosodiethylamine and N-nitrosodibutylamine and may have enhanced esophageal carcinogenesis by N-nitrosodiethylamine. Induction of tumors by N-nitrosodimethylamine and N-nitrosodimethylamine metabolism in vitro in liver slices were not significantly affected by the diet.

¹ This research was supported by Contract NIH-NCI-E-72-2076.

² Supported in part by a Joseph Goldberger Medical Student Research Fellowship awarded by the Committee on Nutrition in Medicine of the A. M. A. Council on Foods and Nutrition.

Received 8/ 6/73. Accepted 10/ 8/73.

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