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The Mechanism of ⁶⁷Ga Association with Lymphocytes¹

Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 21205 [T. M., H. N. W.]; Temple University Health Sciences Center, Section of Nuclear Medicine, Philadelphia, Pennsylvania 19140 [L. M.]; and Massachusetts General Hospital, Boston, Massachusetts 02114 [K. M.]

Human thymus-dependent lymphocytes cultured in vitro were used as a model to study mechanisms of ⁶⁷Ga uptake. Lymphocyte affinity for ⁶⁷Ga was studied in unstimulated cells and cells stimulated by phytohemagglutinin. The evidence suggests that ⁶⁷Ga uptake is linear as a function of ⁶⁷Ga concentration in both stimulated and unstimulated cells and that ⁶⁷Ga associates primarily and tenaciously with the plasma membranes of lymphocytes. In addition, increased ⁶⁷Ga uptake seen in phytohemagglutinin-stimulated cells appears to be associated with changes in the plasma membrane.

¹ Supported by USPHS Grants GM 01496 and GM 10548.

Received 2/20/74. Accepted 6/12/74.