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The Mutagenicity and DNA-modifying Effect of Haloalkanes¹

Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032

A series of haloalkanes, some of them widely used in industry and in the home, are shown to be mutagenic for Salmonella typhimurium and preferentially to inhibit the growth of DNA polymerase-deficient (pol A₁^-) Escherichia coli. It was found that the relative activities of the test substances differed when examined in these systems and that one of the agents was active in the pol A₁^- system only. In view of these results it is suggested that both assays be used in routine screening of environmental agents.

¹ Supported by the Division of Cancer Cause and Prevention, National Cancer Institute (NO1 CP-33395).

² Research Career Development Awardee of the National Institute of General Medical Sciences, USPHS (5 K3-GM29, 024).

Received 3/28/74. Accepted 6/26/74.